Wet massing and granulation equipment
High Shear Mixer Granulator
High shear mixer granulator for pharmaceutical OSD powder mixing, binder addition, wet granulation and discharge to drying equipment.
Short Answer
A high shear mixer granulator combines powder mixing, binder addition and wet granulation in one vessel before discharge to drying or downstream sizing equipment.
Process position
Process Position
The granulator is positioned after raw material dispensing and before fluid bed drying, wet milling or granule transfer.
Step 1
Powder charging
Step 2
Dry mixing
Step 3
Binder addition
Step 4
Wet granulation
Step 5
Discharge
Applications, Benefits And Technical Options
Applications
- Tablet wet granulation
- Capsule granule preparation
- Pilot batch development
- Scale-up from R&D to production
- Granulation line integration
Key Benefits
- Integrated dry mixing and wet granulation step
- Impeller and chopper options for process development
- Discharge and transfer can be matched to dryer layout
- Recipe controls and process monitoring can be scoped
- Documentation support available for project requirements
Technical Options
- Top or bottom drive arrangements depending on design
- Binder spray or liquid addition options
- Jacketed bowl and temperature monitoring options
- Vacuum transfer, wet mill or gravity discharge integration
- PLC/HMI recipe and batch reporting options
Quotation input
What Information Is Needed For Quotation
A clearer URS and layout package helps the engineering team confirm equipment scope, capacity assumptions, containment expectations and documentation needs.
Product name, powder properties, bulk density, particle size range and flowability notes.
Required capacity per batch or per hour, target transfer distance and elevation.
Process layout, room classification expectations and upstream/downstream equipment interfaces.
Containment, dust extraction, cleaning, material contact and documentation expectations.
Utilities, control preference, automation scope and FAT/SAT/IQ/OQ support requirements.
Ready To Discuss A Powder Handling Project?
Send your URS, layout, BOQ, powder characteristics or required capacity. Our engineer will review the process step and suggest suitable powder handling equipment or a complete processing line concept.
FAQ
Frequently Asked Questions
What data is needed to size a high shear granulator?+
Batch size, working volume, product density, binder system, granulation endpoint, cleaning method and discharge route are important inputs.
Can a granulator be supplied with a dryer?+
Yes. The granulator can be quoted as part of a granulation and drying line with transfer, milling and controls included.
Is documentation support available for pharmaceutical projects?+
Documentation support can be included according to project scope, including drawings, material certificates, FAT/SAT records and IQ/OQ support if required.
Related guides
Related Guides
Use these Knowledge Hub articles to compare equipment options, prepare RFQ inputs and connect this page to the wider powder handling process.
What Is Pharmaceutical Powder Handling Equipment?
Pharmaceutical powder handling equipment moves, conditions, weighs, contains and feeds powders between process steps while supporting dust control, cleanability, operator workflow and GMP-oriented documentation.
Read guideHow To Design an OSD Powder Processing Line
An OSD powder processing line should be designed around batch flow, room layout, powder behavior, containment level, cleaning method and interfaces from dispensing through final feed.
Read guideVacuum Conveyor vs Pneumatic Conveyor
Vacuum conveying is commonly selected for enclosed pharmaceutical powder transfer over practical plant distances, while broader pneumatic conveying choices depend on capacity, route, powder behavior and containment needs.
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